Reducing ischaemic damage in rodent ovarian xenografts transplanted into granulation tissue
Identifieur interne : 001619 ( Main/Exploration ); précédent : 001618; suivant : 001620Reducing ischaemic damage in rodent ovarian xenografts transplanted into granulation tissue
Auteurs : Tomer Israely [Israël] ; Nava Nevo [Israël] ; Alon Harmelin [Israël] ; Michal Neeman [Israël] ; Alex Tsafriri [Israël]Source :
- Human Reproduction [ 0268-1161 ] ; 2006-06.
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Abstract
BACKGROUND: Anti-cancer therapies frequently lead to ovarian damage and impaired fertility. To preserve fertility, cryopreservation and subsequent transplantation of the ovaries have been suggested. One of the challenges in ovarian graft transplantation is overcoming the initial ischaemic damage that depletes a significant fraction of the oocyte pool. METHODS AND RESULTS: Follicular survival in ovarian grafts was examined by magnetic resonance imaging (MRI) and fluorescence microscopy in a model system in which rat ovaries were transplanted into nude mice. Transplantation into angiogenic granulation tissue created during wound healing shortened the ischaemic period by 24 h and significantly increased the pool of healthy primordial follicles and the perfused area of the transplanted grafts. Functional blood vessels were detected within the grafts as early as 2 days after transplantation. Gain of function was demonstrated both by growth of the grafts and by the hormonal influence on the host uteri. CONCLUSION: Implantation of ovarian grafts into an angiogenic granulation tissue improved graft vascularization and follicular survival. This procedure/treatment may be used for reducing the ischaemic damage in ovarian transplants, thus prolonging graft functionality and increasing the yield of oocytes that can be easily recovered for fertilization.
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DOI: 10.1093/humrep/del010
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Reprod.</title><idno type="ISSN">0268-1161</idno><idno type="eISSN">1460-2350</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2006-06">2006-06</date><biblScope unit="volume">21</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1368">1368</biblScope><biblScope unit="page" to="1379">1379</biblScope></imprint><idno type="ISSN">0268-1161</idno></series><idno type="istex">2DC3B2535ABCB6E2D127B5DAE9BC7477735C6F36</idno><idno type="DOI">10.1093/humrep/del010</idno><idno type="local">010</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0268-1161</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>animal model</term><term>granulation tissue</term><term>ischaemia–reperfusion injury</term><term>oocyte pool</term><term>ovarian transplantation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND: Anti-cancer therapies frequently lead to ovarian damage and impaired fertility. To preserve fertility, cryopreservation and subsequent transplantation of the ovaries have been suggested. One of the challenges in ovarian graft transplantation is overcoming the initial ischaemic damage that depletes a significant fraction of the oocyte pool. METHODS AND RESULTS: Follicular survival in ovarian grafts was examined by magnetic resonance imaging (MRI) and fluorescence microscopy in a model system in which rat ovaries were transplanted into nude mice. Transplantation into angiogenic granulation tissue created during wound healing shortened the ischaemic period by 24 h and significantly increased the pool of healthy primordial follicles and the perfused area of the transplanted grafts. Functional blood vessels were detected within the grafts as early as 2 days after transplantation. Gain of function was demonstrated both by growth of the grafts and by the hormonal influence on the host uteri. CONCLUSION: Implantation of ovarian grafts into an angiogenic granulation tissue improved graft vascularization and follicular survival. This procedure/treatment may be used for reducing the ischaemic damage in ovarian transplants, thus prolonging graft functionality and increasing the yield of oocytes that can be easily recovered for fertilization.</div></front></TEI><affiliations><list><country><li>Israël</li></country></list><tree><country name="Israël"><noRegion><name sortKey="Israely, Tomer" sort="Israely, Tomer" uniqKey="Israely T" first="Tomer" last="Israely">Tomer Israely</name></noRegion><name sortKey="Harmelin, Alon" sort="Harmelin, Alon" uniqKey="Harmelin A" first="Alon" last="Harmelin">Alon Harmelin</name><name sortKey="Israely, Tomer" sort="Israely, Tomer" uniqKey="Israely T" first="Tomer" last="Israely">Tomer Israely</name><name sortKey="Israely, Tomer" sort="Israely, Tomer" uniqKey="Israely T" first="Tomer" last="Israely">Tomer Israely</name><name sortKey="Neeman, Michal" sort="Neeman, Michal" uniqKey="Neeman M" first="Michal" last="Neeman">Michal Neeman</name><name sortKey="Nevo, Nava" sort="Nevo, Nava" uniqKey="Nevo N" first="Nava" last="Nevo">Nava Nevo</name><name sortKey="Tsafriri, Alex" sort="Tsafriri, Alex" uniqKey="Tsafriri A" first="Alex" last="Tsafriri">Alex Tsafriri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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